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Latest Hematology / Oncology Articles
- Tambotatug Pelitecan in Small-Cell Lung Cancer after Platinum-Based Therapy September 12, 2026Among patients with relapsed small-cell lung cancer after chemotherapy, treatment with tambotatug pelitecan led to longer survival than treatment with topotecan, with fewer adverse events of grade 3 or higher.Yuanyuan Zhao, Hongxu Liu, Xiangjiao Meng, Zhihua Liu, Yan Yu, Yulong Zheng, Longhua Sun, Runxiang Yang, Jian Liu, Yanqiu Zhao, Lin Wu, Lei Yang, Zhiye Zhang, Mingjun Li, Peng Zhang, Yan Zhang, Hua Zhong, Jiuwei Cui, Zhangzhou Huang, Yanwei Yin, Manxiang Li, Fan Tong, Dan Xue, Dongqing Lv, Xufeng Li, Xian Zhang, Steve Chin, Jiaqiang Cai, Tongtong Xue, Yan Huang, Hongyun Zhao, Li Zhang, the TAISHAN-302 Investigators*
- Exa-cel in Children with Transfusion-Dependent β-Thalassemia or Sickle Cell Disease September 10, 2026The authors report the results of interim analyses of two phase 3 studies of exa-cel, a gene-edited cellular therapy, in children with transfusion-dependent β-thalassemia or sickle cell disease.Haydar Frangoul, Josu de la Fuente, Yogi Chopra, Roland Meisel, Persis J. Amrolia, Mattia Algeri, Akshay Sharma, Maria Domenica Cappellini, Selim Corbacioglu, Antonis Kattamis, Stephan Lobitz, Mariane de Montalembert, Damiano Rondelli, Sujit Sheth, Martin H. Steinberg, Mark C. Walters, Kevin Boerner, Tina Liu, Sakellarios Zairis, William Hobbs, Stephan A. Grupp, Franco Locatelli, the CLIMB THAL-141 and CLIMB SCD-151 Study Groups*
- Complete Regression of Hepatoblastoma after Interleukin-15– and Interleukin-21–Coexpressing CAR T-Cell Therapy September 10, 2026A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing interleukin-15 and interleukin-21.David Steffin, Amy N. Courtney, Michelle Choe, Nisha Ghatwai, Magdalena A. Esparza Cerda, Ramy Sweidan, Rajdekar Dhanashree, Huimin Zhang, Natasha Lapteva, Zhuyong Mei, Bambi J. Grilley, Leonid S. Metelitsa, Helen E. Heslop, Malcolm K. Brenner, Andras Heczey
Latest Allergy & Immunology Articles
- Neuroinvasive Trichodysplasia Spinulosa–Associated Polyomavirus Infection September 10, 2026Trichodysplasia spinulosa–associated polyomavirus was identified as a likely cause of neuroinvasive infection in a 16-year-old patient who had undergone renal transplantation.Aaron Bodansky, Natalie Pierson, Venice Servellita, Kaitlin Marquis, Robert Valdovinos, Nahid Hiermandi, Andrew W. Bollen, Ilay Caliskan, Kanish Mirchia, Charles Omura, Jessica Streithorst, Brian LaFranchi, Timothy J. Henrich, Chung-Yu Wang, Bryan Castillo-Rojas, William Bernal, Alexandra Bicki, Erica Winnicki, Marsha Lee, Kelsey Zorn, Sukhman Sidhu, Orit Glenn, Mary Karalius, Matt S. Zinter, Kendall Nash, Michael R. Wilson, Thomas M. Tarro, Joseph L. DeRisi, Charles Y. Chiu
- Case 25-2026: A 65-Year-Old Man with Fever and Rash September 10, 2026A 65-year-old man was admitted to this hospital because of fever, intermittent abdominal pain, and rash. The fever began 5 weeks earlier, and palpable purpura developed 1 week before admission. A diagnosis was made.Jacqueline T. Chu, Robert G. Rasmussen, Jacquelyn M. Nestor, Mack Y. Su
- A Step Forward — Obinutuzumab for Membranous Nephropathy September 10, 2026Membranous nephropathy, the leading cause of nephrotic syndrome in adults, is generally diagnosed through a kidney biopsy in patients presenting with heavy proteinuria, hypoalbuminemia, and edema. Its diagnostic hallmarks include subepithelial immune-complex deposition along the outer aspect of the glomerular basement membrane, which leads to diffuse capillary-wall thickening and a...María José Soler
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