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  • A Step in the Search for the Elusive Holy Grail of Early Detection of Cancer October 8, 2026
    The diagnosis of cancer at earlier stages is generally associated with improved survival. Detecting circulating tumor–derived cell-free DNA (cfDNA) is an established method of monitoring the response to therapy for many cancer types, particularly hematopoietic and metastatic cancers — which leads to the question of whether screening for cfDNA in...
    David J. Hunter
  • Advances in Systemic Treatment of Breast Cancer October 8, 2026
    This review summarizes advances in therapy, including approval or expanded use of targeted agents, improved outcomes with antibody–drug conjugates and immunotherapy, and growing reliance on molecular profiling.
    Sara Alsterlind Hurvitz
  • Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia October 8, 2026
    A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made.
    Ezra M. Cohen, Shohei Fujita, Daniel R. Brown, Vanda F. Torous
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  • Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia October 8, 2026
    A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made.
    Ezra M. Cohen, Shohei Fujita, Daniel R. Brown, Vanda F. Torous
  • Obexelimab and the Promise of Nondepleting B-Cell Therapy in IgG4-Related Disease October 1, 2026
    IgG4-related disease has emerged as one of the clearest human models for understanding the role of B-lineage cells in immune-mediated inflammation. Although glucocorticoids remain effective for inducing remission, relapse during tapering is common, cumulative toxic effects are substantial, and durable disease control remains difficult to achieve. Della-Torre et al.1
    Thomas Dörner
  • An Echo Unheard October 1, 2026
    A 58-year-old woman with previously stable hearing impairment was admitted for rapidly progressive bilateral hearing loss. She reported no headache, vertigo, tinnitus, or dizziness.
    Roni Eichel, Gabriel S. Breuer, Eyal Ben Dori, Merav Weil, Eli Ben-Chetrit