Latest Neuroscience Articles

• Brief Report: Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery June 4, 2026
  A neuroepithelial tumor occurred in a child who had previously received AAV gene therapy for mucopolysaccharidosis type I. Analysis of tumor tissue showed the integration of rearranged AAV vector elements in the gene PLAG1.
  Rebecca C. Ahrens-Nicklas, Chelsea Kotch, Aoife M. Roche, John K. Everett, Shantan Reddy, Mariarita Santi, Peter J. Madsen, Cristina Martos-Rus, Carolyn M. Yrigollen, Juliana C. Small, Sarah McCague, Beverly L. Davidson, Benjamin J. Samelson-Jones, Lea F. Surrey, Marilyn Li, Can Ficicioglu, Raymond Wang, Frederic D. Bushman, Lindsey A. George
• Emerging Era for Polymyalgia Rheumatica and GCA — Interleukin-17A Targeting June 3, 2026
  Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rheumatica and giant-cell arteritis (GCA), owing to...
  Yoshiya Tanaka
• Resolution of PML after Treatment with Virus-Specific T Cells and HCT May 28, 2026
  Two patients with inborn errors of immunity and progressive multifocal leukoencephalopathy received polyomavirus-specific T cells, followed by allogeneic hematopoietic transplantation with good neurologic outcomes.
  Corina E. Gonzalez, Anita Fletcher, Tonya L. Jenkins, Sara Zahraeifard, Rose Peterson, Milo Taylor, Christine Jones, Amanda Urban, Daniele Avila, Mauricio Campillay, Jamie Wilhelm, Ariane Soldatos, Jens Kuhle, Poorva Jain, Sydney Corey, Jenna R.E. Bergerson, Daniel S. Reich, Steven Highfill, David Stroncek, Anh Dinh, Stefania Pittaluga, Heidi H. Kong, Helen C. Su, Luigi D. Notarangelo, Sung-Yun Pai, Michael Grimley, Alexandra F. Freeman, Irene Cortese