In 1959, an article entitled "An Anaphylactoid Reaction to Vancomycin" hypothesized that vancomycin-induced histamine release from mast cells had clinical manifestations similar to those of anaphylaxis but less severe. The author named this reaction "Red Man Syndrome," reflecting the diffuse…
Patients with cold agglutinin disease, a rare autoimmune hemolytic anemia, often have chronic anemia, profound fatigue, and acute hemolytic crisis. These patients may also have agglutination-mediated acrocyanosis and a higher risk of thromboembolism and early death. Cold agglutinin disease is…
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, clonal, nonmalignant hematologic disease characterized by complement-mediated hemolysis (with or without hemoglobinuria), fatigue, increased susceptibility to thrombosis, and some degree of bone marrow dysfunction. PNH results from the…
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