Antibody-Mediated Rejection in Renal Transplantation: Immune Mechanisms, Diagnostic Criteria, & Therapeutic Advances: A Clinical Olympics℠

Program Overview

Although over 100,000 renal transplants are performed worldwide each year, only a fraction of recipients are living with functioning renal grafts. Approximately 40% of renal transplants fail within 10 years. Chronic, or late, renal graft rejection is a leading cause of failure. Management of chronic active antibody-mediated rejection (AMR) is a major challenge due to the lack of both approved treatment options and clinical evidence informing current guidelines. In this fast-paced, highly interactive activity, Drs. Jordan, Djamali, and Schinstock will take you through the pathophysiology, diagnosis, and emerging therapeutics for chronic active AMR.

0.75 CE Credit(s)
Expires: August 9, 2023

Target Audience

This activity is intended for transplant, nephrology, general surgery, and internal medicine clinicians managing transplant patients with antibody-mediated rejection (AMR).

Educational Objectives

Upon completion of this activity, participants should be better able to:

  • Identify the pathophysiology of chronic active antibody-mediated rejection (AMR) that leads to deleterious clinical manifestations in kidney transplant patients
  • Apply Banff diagnostic criteria for chronic active AMR in renal allografts
  • Examine the potential role of emerging therapeutic approaches in the management of chronic active AMR

Activity Faculty


Stanley C. Jordan, MD, FASN, FAST

Director, Nephrology & Transplant Immunology
Medical Director, Kidney Transplant Program
Cedars-Sinai Medical Center
Los Angeles, CA


Arjang Djamali, MD

Chair, Department of Medicine
Maine Medical Center
Portland, ME


Carrie A. Schinstock, MD

Associate Professor
Division of Nephrology and Hypertension
Mayo Clinic
Rochester, MN

Supporter Statement

This activity is supported by an independent educational grant from CSL Behring LLC.

Provider Statement

This activity is provided by RMEI Medical Education, LLC

Disclosure of Financial Relationships


Planners and Managers

Method of Participation and Request for Credit

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. 

Disclaimer Statement

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. 

Copyright Statement

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