Quelling the Vicious Vortex: Targeting Neutrophil Serine Proteases in Non-Cystic Fibrosis Bronchiectasis: A Clinical Forum®

The goal of this activity is to raise awareness of the symptoms and burden of non-cystic fibrosis bronchiectasis (NCFBE), as well as new treatment targets. Diagnostic delay leads to a cycle of frequent exacerbations during which the vicious vortex of neutrophil-mediated inflammation and lung damage occurs. New research is providing insights on the pathophysiology of NCFBE, including the role of neutrophilic inflammation and activation of neutrophil serine proteases (NSPs) by mediators, such as dipeptidyl peptidase 1 (DPP-1). Novel treatment approaches for inhibiting DPP-1 in NCFBE offer the potential for improving quality of life and preserving lung function.