What Lies Beneath: Diagnostic Challenges of Prurigo Nodularis

Program Overview

Prurigo nodularis (PN) is a relatively rare skin condition characterized by an intense, unrelenting itch and the development of cutaneous nodules. Classically, it has been difficult to diagnose and is associated with a wide range of comorbidities. In this Clinical Reflections® activity, you will be presented with a case and challenged to reflect back on how it could have been better handled. Experts in PN will share their insights on the underlying type 2 inflammation and immune dysregulation driving PN, as well as guideline-based strategies to achieve an accurate diagnosis.

Credit Expired

Target Audience

Dermatology and primary care clinicians

Educational Objectives

Upon completion of this activity, participants should be better able to:

  • Utilize strategies to improve prurigo nodularis (PN) symptom recognition and diagnosis
  • Identify elements of type 2 inflammation that play a role in PN pathogenesis that may be amenable to treatment

Activity Faculty


Shawn Kwatra, MD

Associate Professor, Dermatology and Oncology
Director, Johns Hopkins Itch Center
Johns Hopkins University School of Medicine
Baltimore, MD


Sarah S. Chisolm, MD

Assistant Professor and Director, Clinical Trials, Department of Dermatology
Emory University
Managing Director, ITCH-E (Itch Translational and Clinical Home at Emory)
Staff Physician, VISN 7, VA
Emory University Hospital
Atlanta, GA



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