What Lies Beneath: Diagnostic Challenges of Prurigo Nodularis

Program Overview

Prurigo nodularis (PN) is a relatively rare skin condition characterized by an intense, unrelenting itch and the development of cutaneous nodules. Classically, it has been difficult to diagnose and is associated with a wide range of comorbidities. In this Clinical Reflections® activity, you will be presented with a case and challenged to reflect back on how it could have been better handled. Experts in PN will share their insights on the underlying type 2 inflammation and immune dysregulation driving PN, as well as guideline-based strategies to achieve an accurate diagnosis.

Credit Expired
0.5 CE Credit(s)
Expires: December 14, 2023

Target Audience

Dermatology and primary care clinicians

Educational Objectives

Upon completion of this activity, participants should be better able to:

  • Utilize strategies to improve prurigo nodularis (PN) symptom recognition and diagnosis
  • Identify elements of type 2 inflammation that play a role in PN pathogenesis that may be amenable to treatment

Activity Faculty


Shawn Kwatra, MD

Associate Professor, Dermatology and Oncology
Director, Johns Hopkins Itch Center
Johns Hopkins University School of Medicine
Baltimore, MD


Sarah S. Chisolm, MD

Assistant Professor and Director, Clinical Trials, Department of Dermatology
Emory University
Managing Director, ITCH-E (Itch Translational and Clinical Home at Emory)
Staff Physician, VISN 7, VA
Emory University Hospital
Atlanta, GA


Supporter Statement

This activity is supported by an educational grant from Sanofi and Regeneron Pharmaceuticals.

Provider Statement

This activity is provided by RMEI Medical Education, LLC.

Disclosure of Financial Relationships


Planners and Managers

Disclosure of Financial Relationships 

RMEI Medical Education, LLC (RMEI) requires instructors, planners, managers, and others in control of educational content to disclose all their financial relationships with ineligible companies over the previous 24 months. All identified financial relationships are thoroughly vetted and mitigated according to RMEI policy. 


Sarah S. Chisolm, MD, has relevant financial relationships with AbbVie, AstraZeneca, CSL Vifor, Galderma, Janssen Pharmaceuticals, Kimberly-Clark, Kiniksa Pharmaceuticals, Pfizer, Regeneron, Sanofi, Trevi Therapeutics, VYNE Therapeutics, Inc., formerly Menlo Therapeutics (Advisor); Amgen, Incyte Corporation, Pfizer (Researcher).

Shawn Kwatra, MD, has relevant financial relationships with AbbVie, Aslan Pharmaceuticals, Arcutis Biotherapeutics, Inc., Castle Biosciences, Celldex Therapeutics, Inc., Galderma, Genzada Pharmaceuticals USA, Inc., Incyte Corporation, Johnson & Johnson, Leo Pharma, Novartis, Pfizer, Regeneron, Sanofi (Consultant); Galderma, Incyte Corporation, Pfizer, Sanofi (Grant/Research Support).

All of the relevant financial relationships listed for these individuals have been mitigated according to RMEI policies. 

Planners and Managers

RMEI Medical Education, LLC planners and managers have no relevant financial relationship(s) with ineligible companies to disclose.

Joint Accreditation Statement 

In support of improving patient care, RMEI Medical Education, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Credit Designation

Physician Continuing Medical Education 
RMEI Medical Education, LLC designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Continuing Nursing Education 
The maximum number of hours awarded for this Continuing Nursing Education activity is 0.5 contact hour(s).

Instructions for Receiving Credit 

In order to receive credit, participants must review the activity content and successfully complete both the post-test and evaluation. You must score 67% or higher on the post-test to receive credit for this activity. If you have questions about this activity, please contact RMEI at [email protected]. 

Users must: 

  • Read the learning objectives and faculty disclosures 
  • Participate in the activity 
  • Complete the activity evaluation and attest to credit

There is no fee to participate. 



*The expense for this gift card is solely funded by RMEI Medical Education, LLC. 
No supporter funding was used for the expense of this gift card. 

Rules and Regulations 
This sweepstakes is managed by RMEI Medical Education, LLC (RMEI), a jointly accredited provider. The winner will be selected via automated random drawing on a quarterly basis from among all eligible entries and notified through the contact information provided. In accordance with our privacy policy, we do not share your information with any third parties. By entering the sweepstakes, you grant RMEI permission to use your e-mail address to reach you for notification and prize fulfillment. Only individuals who complete the evaluation forms and provide contact information will be eligible to win. Open to those who have a US postal address and who are 18 years or older. Only one prize per person and per household will be awarded. The prize will be a $100 Amazon gift card.   

Method of Participation and Request for Credit

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. 

Disclaimer Statement

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. 

Copyright Statement

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