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  • Precision Therapy in Locally Advanced Rectal Cancer September 1, 2020
    In this issue of JAMA Oncology, Diefenhardt and colleagues report a post hoc analysis of the previously published German CAO/ARO/AIO-04 trial and found that the ability of patients with rectal cancer to complete planned neoadjuvant (but not adjuvant) therapy was associated with improved disease-free survival. The authors concluded “the findings emphasize the need for appropriate […]
  • Treatment Adherence and Oncologic Outcomes in Rectal Cancer September 1, 2020
    This post hoc analysis of a randomized phase 3 trial analyzes the association of treatment adherence with disease-free survival among patients with rectal cancer in the CAO/ARO/AIO-04 trial.
  • Time to Focus on Value-Based Metrics for Cancer Care? September 1, 2020
    This Viewpoint stresses the importance of the multiple dimensions of value-based, patient-centered, quality health care for patients with cancer.
  • Cancer Survivorship—Considering Mindsets September 1, 2020
    To the Editor We commend Baker for his call to action to “do better” in cancer survivorship care. Baker advocates for an increased focus on treatment-specific late effects; this work can promote precision in survivorship care by targeting prevention efforts and increasing medical surveillance for those with elevated biomedical risk.

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RSS The New England Journal of Medicine | Primary Care/Hospitalist/Clinical Practice
RSS The New England Journal of Medicine Rheumatology
  • Tolerance in the Age of Immunotherapy September 17, 2020
    The induction and maintenance of robust immune tolerance has been the holy grail of immunology for decades. In the absence of robust unresponsiveness of the immune system to self antigens (immune tolerance), uncontrolled reactivity can lead to disorders like food allergies and autoimmune diseases.…
  • Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus September 17, 2020
    Systemic lupus erythematosus is a chronic systemic autoimmune disease characterized by autoantibody production and immune-complex–mediated tissue damage. Autoantibody-secreting plasma cells are increasingly recognized as essential drivers of chronic inflammation in lupus, but targeting them…
  • Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis September 17, 2020
    Systemic lupus erythematosus (SLE), a chronic autoimmune disease characterized by loss of immune tolerance, leads to multisystem inflammation and organ injury. Lupus nephritis, which occurs in 25 to 60% of patients with SLE, is the most common severe manifestation of SLE and a major cause of…
  • Belimumab as Add-on Therapy in Lupus Nephritis September 17, 2020
    Nephritis, the most common serious manifestation of systemic lupus erythematosus (SLE), affects up to 50% of patients with this condition. Proliferative lupus nephritis typically manifests with microscopic hematuria, nonnephrotic proteinuria, renal insufficiency, and hypertension, whereas…

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