Medical News, Journals & Upcoming Events
- Prescription Opioid Use and Risk for Major Depressive Disorder November 11, 2020This mendelian randomization analysis investigates the potential bidirectional associations between the genetic liability for prescription opioid and other nonopioid pain medications and both major depressive disorder and anxiety and stress-related disorders using genetically based methods
- Five Things to Know When a Psychiatric Patient Is Prescribed Opioids for Pain November 11, 2020This essay describes how psychiatrists can play an important role in optimizing care for patients who have been prescribed opioids for chronic pain.
- Use of Genetically Informed Methods to Clarify the Nature of the Association Between Cannabis Use and Risk for Schizophrenia November 4, 2020This Viewpoint reviews reports that relied on 4 genetic methods capable of addressing the nature of the cannabis-schizophrenia association.
- Psilocybin-Assisted Supportive Psychotherapy in the Treatment of Major Depression—Quo Vadis? November 4, 2020In this issue of JAMA Psychiatry, Davis and colleagues at the Johns Hopkins Center for Psychedelic and Consciousness Research have contributed a timely and important proof-of-concept randomized clinical trial on the effects of psilocybin-assisted supportive psychotherapy for the treatment of major depression. The authors reported rapid relief of depressive symptoms and high rates of response […]
- Urinary Tetrahydrocannabinol After 4 Weeks of a Full-Spectrum, High-Cannabidiol Product in an Open-Label Trial November 4, 2020This cohort study examines whether consumption of a high-cannabidiol product resulted in detectable amounts of Δ9-tetrahydrocannabinol metabolites in the urine samples of participants.
- Plinabulin vs Pegfilgrastim for Prevention of Chemotherapy-Induced Neutropenia in Adults With NSCLC November 12, 2020This randomized phase 2 clinical trial assesses the efficacy and safety of plinabulin compared with pegfilgrastim for the prevention of chemotherapy-induced neutropenia following docetaxel chemotherapy in adult patients with non–small lung cancer.
- Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib November 12, 2020This randomized clinical trial assesses the efficacy of nivolumab plus ipilimumab in the treatment of patients with advanced hepatocellular carcinoma who have been previously treated with sorafenib.
- Watery Diarrhea in a Patient With Metastatic Appendiceal Adenocarcinoma November 1, 2020A 72-year-old man with metastatic appendiceal adenocarcinoma undergoing chemotherapy with capecitabine plus oxaliplatin presents with lower abdominal pain and watery, large-volume diarrhea up to 15 times per day for the previous 3 weeks. What is your diagnosis?
- Demystifying the Role of Tumor Mutational Burden for Immunotherapy Selection November 1, 2020To the Editor In their Invited Commentary, Waqar and Govindan describe some of the confounding factors that may have influenced the outcomes of 2 pivotal studies—the Checkmate 227 study (NCT02453282) and the MYSTIC study (NCT02477826)—that evaluated the ability of tumor mutational burden (TMB) to enrich survival in patients treated with immunotherapy vs standard of care. […]
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- Risk Factors for SARS-CoV-2 in a Statewide Correctional System November 24, 2020To the Editor: More than 2 million persons are incarcerated in the United States, and many of them are vulnerable to infection because of chronic medical conditions. Correctional settings are considered to be high-risk environments for transmission of the severe acute respiratory syndrome…
- Case 36-2020: A 72-Year-Old Woman with Dark Urine and Weakness November 19, 2020Presentation of Case. Dr. Julian S. Haimovich (Medicine): A 72-year-old woman with a history of rheumatic heart disease was evaluated at this hospital because of weakness and dark urine. The patient had been in her usual state of health, which included recreational swimming and hiking, until 3…
- Physician–Public Defender Collaboration — A New Medical–Legal Partnership November 19, 2020Mr. A. a 45-year-old man with a history of benzodiazepine use disorder, was brought to the hospital after having a grand mal seizure while awaiting trial in the holding cell of a municipal courthouse. After being arrested 3 days earlier, he had been held for 2 days in the police station, where he…
- Transition Zone in Hirschsprung’s Disease November 19, 2020Figure 1.
- Wandering Spleen November 19, 2020Figure 1.
- Covid-19–Associated Myopathy Caused by Type I Interferonopathy November 20, 2020To the Editor: The syndrome of Covid-19 infection includes myalgias and elevated creatine kinase levels in at least a third of patients. Whether the elevation in creatine kinase level is caused by viral infection of muscle, toxic effects of cytokines, or another mechanism is unclear. There are few…
- Necrotizing Scleritis November 5, 2020Figure 1.
- Case 34-2020: A 74-Year-Old Man with Chronic Kidney Disease October 29, 2020Presentation of Case. Dr. Eugene P. Rhee: A 74-year-old man was evaluated in the nephrology clinic of this hospital because of chronic kidney disease. The patient had been in his usual state of health when he was referred to the nephrology clinic of this hospital for a preoperative evaluation of…
- Keratoconjunctivitis Sicca in Sjögren’s Syndrome October 22, 2020Figure 1.