The advent of CAR T-cell therapy and bispecific antibodies has revolutionized care for patients with B-cell non-Hodgkin’s lymphomas, but they also come with inflammatory and neurological safety concerns that may be unfamiliar to emergency department clinicians. In this activity, clinicians will learn directly from Drs. Joshua Brody and Jeremy Abramson how to recognize, evaluate, and treat these adverse reactions according to guidelines.
Upon completion of this activity, participants should be better able to:
Director, Lymphoma Immunotherapy Program
Tisch Cancer Institute at Mount Sinai
Faculty, Icahn Genomics Institute
Icahn School of Medicine at Mount Sinai
Hess Center for Science and Medicine
Mount Sinai Hospital
New York, NY
Director, Center for Lymphoma
Massachusetts General Hospital
Associate Professor, Medicine
Harvard Medical School
Boston, MA
RMEI Medical Education, LLC (RMEI) requires instructors, planners, managers, and others in control of educational content to disclose all their financial relationships with ineligible companies over the previous 24 months. All identified financial relationships are thoroughly vetted and mitigated according to RMEI policy.
Jeremy S. Abramson, MD, MMSc, has relevant financial relationships with AbbVie, ADC Therapeutics, AstraZeneca, BeiGene, BMS, Celgene, Cellectar, Eli Lilly, Foresight Diagnostics, Genentech, Gilead, Incyte, Interisu, Janssen, Novartis, Roche, Seagen (Consultant); BMS, Celgene, Cellectis, Genentech, Merck, Mustang Bio, Regeneron, Seagen, Takeda (Grants/Research).
Joshua Brody, MD, has relevant financial relationships with Kite Pharma, Genentech (Grants/Research).
All of the relevant financial relationships listed for these individuals have been mitigated according to RMEI policies.
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Physician Continuing Medical Education
RMEI Medical Education, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 medical knowledge MOC point(s) in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
To receive credit, participants must review the activity content and successfully complete both the post-test and evaluation. A statement of credit will be available to print immediately. You must score 75% or higher on the post-test to receive credit for this activity. If you have questions about this activity, please contact RMEI at [email protected].
Users must:
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This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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