Preventing and Treating Acute GvHD: A Discussion of Real-World Cases

Acute graft-versus-host disease (aGvHD) is a common complication associated with allogenic hematopoietic stem cell transplant (allo-HSCT). The skin, GI tract, and liver are often affected despite prophylaxis. Corticosteroids, usually at high doses, comprise the mainstay of first-line treatment for most patients, but this is often intolerable due to infectious complications, immunosuppression, and adverse events. Despite treatment, many patients may go on to develop recurrent aGvHD or steroid-refractory disease. In this activity, an interprofessional expert panel discuss a series of crowd-sourced cases of challenging aGvHD from a medical, pharmacy, and PA perspective. They will also discuss emerging prophylactic agents and therapies for aGvHD.