Preventing and Treating Acute GvHD: A Discussion of Real-World Cases

Program Overview

Acute graft-versus-host disease (aGvHD) is a common complication associated with allogenic hematopoietic stem cell transplant (allo-HSCT). The skin, GI tract, and liver are often affected despite prophylaxis. Corticosteroids, usually at high doses, comprise the mainstay of first-line treatment for most patients, but this is often intolerable due to infectious complications, immunosuppression, and adverse events. Despite treatment, many patients may go on to develop recurrent aGvHD or steroid-refractory disease. In this activity, an interprofessional expert panel discuss a series of crowd-sourced cases of challenging aGvHD from a medical, pharmacy, and PA perspective. They will also discuss emerging prophylactic agents and therapies for aGvHD.

1.0 CE Credit(s)
Expires: June 19, 2025

Target Audience

Hematology, hematology/oncology, transplantation clinicians

Educational Objectives

Upon completion of this activity, participants should be better able to:

  • Select guideline congruent treatment for hematopoietic stem cell transplant (HSCT) recipients according to their grade of acute graft-versus-host disease (aGvHD)
  • Identify the potential role of new data and ongoing clinical trials of emerging therapies in addressing unmet needs in post-HSCT aGvHD management
  • Integrate the unique roles and responsibilities of interprofessional care team members when managing HSCT-recipients with aGvHD

Activity Faculty

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Carrie L. Kitko, MD 

Associate Professor, Pediatrics and Hematology/Oncology
Ingram Professorship, Pediatric Oncology, Department of Pediatrics
Medical Director, Pediatric Stem Cell Transplantation Program
Vanderbilt University Medical Center
Nashville, TN

136-24-1347-VL-001 Faculty Headshot-RGB-KGatwood

Katie S. Gatwood, PharmD, BCOP

Clinical Pharmacist Specialist, Stem Cell Transplant & Cellular Therapy
Vanderbilt University Medical Center
Nashville, TN

136-24-1347-VL-001 Faculty Headshot-RGB-Yennaco

Christine Yennaco, PA-C, MPH, MCHS

Associate Director, Advanced Practice Providers – BMT & Immunotherapy
Fred Hutchinson Cancer Center
Teaching Associate, UW Medicine
University of Washington
Seattle, WA

Supporter Statement

Supported by an independent educational grant from CSL Behring LLC.

Provider Statement

Provided by RMEI Medical Education, LLC

Disclosure of Financial Relationships

RMEI Medical Education, LLC (RMEI) requires instructors, planners, managers, and others in control of educational content to disclose all their financial relationships with ineligible companies over the previous 24 months. All identified financial relationships are thoroughly vetted and mitigated according to RMEI policy.


Katie S. Gatwood, PharmD, BCOP, has relevant financial relationship(s) with BiolineRx, Jazz Pharmaceuticals, Kite Pharma, Sanofi (Speaker).

Carrie L. Kitko, MD, has relevant financial relationship(s) with Horizon Therapeutics, Incyte (Advisor).

Christine Yennaco, PA-C, MPH, MCHS, has no relevant financial relationship(s) with ineligible companies to disclose.

All of the relevant financial relationships listed for these individuals have been mitigated according to RMEI policies.

Planners and Managers

RMEI Medical Education, LLC planners and managers have no relevant financial relationship(s) with ineligible companies to disclose.

Joint Accreditation Statement 

In support of improving patient care, RMEI Medical Education, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Credit Designation

Physician Continuing Medical Education 
RMEI Medical Education, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Continuing Pharmacy Education 
RMEI Medical Education, LLC designates this continuing education activity for 1.0 contact hour(s) (0.10 CEUs) of the Accreditation Council for Pharmacy Education.
Universal Activity Number – JA4008290-0000-24-004-H01-P
Type of Activity: Knowledge

Continuing Nursing Education 
The maximum number of hours awarded for this Continuing Nursing Education activity is 1.0 contact hour(s).

American Board of Internal Medicine Maintenance of Certification 

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 medical knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.


Interprofessional Continuing Education 

This activity was planned by and for the healthcare team, and learners will receive 1.0 Interprofessional Continuing Education (IPCE) credit for learning and change.

Method of Participation and Request for Credit

To receive credit, participants must review the activity content and successfully complete both the post-test and evaluation. A statement of credit will be available to print immediately. You must score 66% or higher on the post-test to receive credit for this activity. If you have questions about this activity, please contact RMEI at [email protected].

Users must:

  • Read the learning objectives and faculty disclosures
  • Participate in the activity
  • Complete the activity evaluation

There is no fee to participate.


*The expense for this gift card is solely funded by RMEI Medical Education, LLC. 
No supporter funding was used for the expense of this gift card. 

Rules and Regulations

This sweepstakes is managed by RMEI Medical Education, LLC (RMEI), a jointly accredited provider. The winner will be selected via automated random drawing on a quarterly basis from among all eligible entries and notified through the contact information provided. In accordance with our privacy policy, we do not share your information with any third parties. By entering the sweepstakes, you grant RMEI permission to use your e-mail address to reach you for notification and prize fulfillment. Only individuals who complete the evaluation form and provide contact information will be eligible to win. Open to those who have a US postal address and who are 18 years or older. Only one prize per person and per household will be awarded. The prize will be a $100 Amazon gift card

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. 

Disclaimer Statement

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. 

Copyright Statement

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